Dynamic Processing of Displacement Loops during Recombinational DNA Repair
نویسندگان
چکیده
منابع مشابه
Focus on recombinational DNA repair.
Introduction Homologous recombination (HR) has a crucial role in chromosome maintenance by promoting error-free repair of DNA double-strand breaks (DSBs) and single-strand gaps. DNA strand breaks occur spontaneously during normal cellular processes, such as DNA replication, or when cells are treated with DNA damaging agents, and are essential intermediates in several programmed genome rearrange...
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The recent finding of a role for the recA gene in DNA replication restart does not negate previous data showing the existence of recA-dependent recombinational DNA repair, which occurs when there are two DNA duplexes present, as in the case for recA-dependent excision repair, for postreplication repair (i.e., the repair of DNA daughter-strand gaps), and for the repair of DNA double-strand break...
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Deoxyribonucleic acid (DNA) damage is a common occurrence in all cells. A bacterial cell growing in an aerobic environment will suffer 3000–5000 DNA lesions per cell per generation (most of them oxidative in origin). Most of this damage is faithfully repaired by specialized DNA repair systems; however, replication forks will occasionally encounter unrepaired DNA lesions. Because DNA polymerase ...
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Recombinational DNA repair is both the most complex and least understood of DNA repair pathways. In bacterial cells grown under normal laboratory conditions (without a DNA damaging treatment other than an aerobic environment), a substantial number (10-50%) of the replication forks originating at oriC encounter a DNA lesion or strand break. When this occurs, repair is mediated by an elaborate se...
متن کاملEarly Days of DNA Repair: Discovery of Nucleotide Excision Repair and Homology-Dependent Recombinational Repair
The discovery of nucleotide excision repair in 1964 showed that DNA could be repaired by a mechanism that removed the damaged section of a strand and replaced it accurately by using the remaining intact strand as the template. This result showed that DNA could be actively metabolized in a process that had no precedent. In 1968, experiments describing postreplication repair, a process dependent ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2019
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2019.01.005